A romantic couple host a party in which things go horribly wrong. Their guests die in gruesome ways. Rather than turn themselves in, and languish in prison, they decide to go on the run and live the rest of their free days together. In their flight they encounter countless horror villains and monsters, but ways never before depicted in movies. 
If you are interested in acquiring this movie, make sure that you get the DVD that has the cover shown. Do NOT get the DVD that has dolls on the cover. If you already own that version, and if you are over 18, then Bill Zebub will trade your version with the re-make. He is very eager to destroy those early movies. The re-make is a completely new movie. It is not a re-edit.
Bill Zebub had written the script before he had read Homer's Odyssey, but he described the story as an Odyssey when people asked for a summary. If only he knew how fitting that word was. The romantic couple fleeing law enforcement embarked on a cosmic journey, much like the Greek classic.
The :"Worst Horror Movie Ever Made" script isn't directly a story of "nostos" (going home) - but that may be because unlike Odysseus, Bill is traveling WITH his wife, not TO his wife.
The coincidental similarities also extend to the end, but such things should not be discussed here because they may spoil the anticipation.
Although there are sophisticated ideas and complex webs of plot, the movie has usually been obtained by people who were seeking low-brow entertainment. There is plenty of that in this generously long saga. But more asute viewers know that the absurdist approach has many more levels than what shallow viewers consider to be foolish. 
The nearly constant nudity may seem, on the surface, to be a gimmick. But it was an exaggerated statement. In the early days of Bill Zebub's career, he overheard the CEO of a very bad movie-distribution company advise one of his low-level producers to put gore and nudity within the first 5 minutes of the next movie because that would increase the chances of an indie movie getting accepted into a video rental chain (that shall not be mentioned here). The "producer" acted on the advice., but his movie did not get accepted by that video chain. Shit is shit, no matter how much perfume you put on it. But the incident was never forgotten by Bill Zebub. When he considered story elements for teh script, he also wrote notes about the stupid side of the movie business.
So the abundant nudity has multiple levels of meaning. On the surface, it makes the video pleasant for male viewers. It is also comical because it is present without any obvious reason (seemingly overly gratuitous). But it's really there to ridicule the silly adice that Bill Zebub had overheard. (Nudity was not present in the first version of the film, which again, you should never ever watch).
This was the first movie in American history to have made a joke about 9/11. That joke was the reason why the movie did not play a large film festival. If the joke were never made, thousadns of new eyes would have been exposed to Bill Zebub's absurdist masterpiece. But the movie was still praised by many prominent journalists and magazines, among which was the Gore-met from Rue Morgue magazine in Canada. Wherever the movie played, crowds applauded the nerve and creativity.
Bill Zebub wanted the movie to be enjoyed by cool people who watched it alone the first time, and then to be enjoyed again in a crowd setting, especially if an uptight, or dense person were present. At the time, it was still considered daring to ridicule religion, namely christianity. But even by the jaded standards of today, what you see Jesus do with the hole in his hand is still eye-popping.
The blasphemous humor may seem, on the surface, to be purely for shock value, or juvenile. That's ok, because if shallow-thinkers become offended, they feel better when they can just dismiss the material as "immature" (and for the other kind of shallow-thinkers who don't get offended, it feels good for them not to think about anything deeper when they laugh.)
But there are some points that Bill Zebub injects.. An example of that is a scene in which two overzealous (christian) soldiers ridicule another religion and point out how stupid those other beliefs are, yet they do not see how silly their own (christian) beliefs are to people outside of their religion. But the scene is not preachy, and it doesn't feel like a moral is being shoved down your throat. It's in an absurd setting, so the mood never should stray from a "what-the-hell-am-I-watching" kind of vibe.
Bill Zebub considers it very important for you to always feel superior to the movie that you are watching, rather than feeling that the movie is superior to you. You get from it what you want. Stay at the level that makes you happy.
Until 2011 the movie was available only in full-screen format. That offering is discontinued, but supplies of it are still available. A widescreen version was made , and it also contains a bonus movie "Assmonster." (a full feature). Bill Zebub also dug up some more bloopers and out-takes for it, and there are a some extra goodies on there as well.
If you want to read a HUGE amount of extra information about the movie, register, or log in, and you will see a ton of text below this article.